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. 2020 Aug 4;16(8):e1008732. doi: 10.1371/journal.ppat.1008732

Fig 4. Mechanisms of antibody-mediated intracellular neutralisation.

Fig 4

(A) Intracellular neutralisation of rotavirus by VP6-specific IgA in wild type (WT) and TRIM21 knockout (TRIM21KO) MA104 cells. (B) Intracellular neutralisation by VP6-specific IgG in WT and TRIM21KO knockout MA104 cells. (C) Intracellular neutralisation by WT or non-binding TRIM21 IgG (H433A). (D) Amounts of EDIM virus shedding three days post infection as detected by faecal antigen ELISA in naïve and pre-DLP-immunized, WT (9–10 mice per group) as well as TRIM21KO mice (5 mice per group). (E) EDIM shedding on days 1–7 post infection in WT and TRIM21KO BALB/c mice pre-immunized with DLPs. Horizontal lines represent mean and standard error, *** p = < 0.001, * p = < 0.05, NS not significant.