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. 2020 Aug 14;6(33):eabb4922. doi: 10.1126/sciadv.abb4922

Fig. 4. The hair-bundle creep is uncorrelated with slow adaptation in vestibular hair cells when stimulated with flexible glass fibers.

Fig. 4

(A) Schematic representation of the experimental setup during the recording of MET currents in vestibular hair cells when stimulated with a flexible fiber. (B) Image of the vestibular hair bundle used for the recording in (C) with a black line to show where the bundle displacement was analyzed. Scale bar, 2 μm. (C) Currents and bundle displacements from the same cell in a P21 gerbil utricle when stimulated with a flexible glass fiber (0.139 mN/m stiffness) at +80 mV (red) and −80 mV (black). Marked traces (violet and blue) highlight a similar step size and are directly compared below. (D) Summary plots of the current properties for the stimulation eliciting ~50% Imax fit with a double exponential decay equation. The left plot summarizes the percentage of adaptation at −80 mV and +80 mV. Fast (τ1) and slow (τ2) adaptation time constants at −80 mV, as well as the Imax at −80 mV and +80 mV, are shown. (E) Summary plots of the bundle motion properties. Gray lines connect data points for a given cell, with cells shown in (A) marked. Bars represent mean ± SD. **P ≤ 0.01, ****P ≤ 0.0001. Number of cells (animals): 13 (13).