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. 2020 Aug 13;7(6):e872. doi: 10.1212/NXI.0000000000000872

Figure 2. Patients with MS and their siblings have increased risk of high EBNA-1 titers compared with spouses.

Figure 2

(A) OR for high EBNA-1 IgG titers (>75th percentile) is increased in patients with MS in both age categories and siblings younger than 50 years of age compared with spouses, suggesting that patients with MS and their siblings are more likely to have higher EBNA-1 IgG titers compared with spouses. (B) No differences in OR for high VZV IgG titers were found between patients with MS and siblings in comparison to the spouses. ORs were calculated by means of logistic regression analysis and GLM were used for between-group comparisons with Bonferroni-corrected and adjusted p-values for gender, disease status, and household. The whiskers indicate 95% CI. Dashed line in each graph represents the reference group (spouses). EBNA-1 = EBV nuclear antigen 1; GLM = generalized linear model; IgG = immunoglobulin; VZV = varicella zoster virus.