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. 2020 Aug 13;7(6):e872. doi: 10.1212/NXI.0000000000000872

Figure 3. HLA-DRB1*1501 carriership is associated with high EBNA-1 IgG titers.

Figure 3

(A) ORs for the association between HLA-DRB1*1501 carriership and high EBNA-1 IgG titers were calculated for patients with MS, siblings, and spouses in 2 age categories. HLA-DRB1*1501 carriership is associated with high EBNA-1 IgG titers in old patients with MS and siblings. (B) OR for high EBNA-1 IgG titers (>75th percentile) is increased in young patients with MS vs spouses in both HLA-DRB1*1501-positive and negative individuals. In older patients with MS compared with controls, OR for high EBNA-1 IgG titers is only increased in HLA-DRB1*1501-positive individuals. (C) HLA-DRB1*1501 is not associated with high VZV IgG titers in all study groups. Logistic regression analyses were performed to calculate ORs, and GLM was used for between-group comparisons with Bonferroni corrected and adjusted p-values for gender, disease status and household. The whiskers indicate 95% CI. EBNA-1 = EBV nuclear antigen 1; GLM = generalized linear model; IgG = immunoglobulin; VZV = varicella zoster virus.