Table 3.
Microfiladermia: Intention to Treat
| IVM annual | IVM semiannual | IVM + ALB annual | IVM + ALB semiannual | P Value | ||
|---|---|---|---|---|---|---|
| Baseline | n | 68 | 68 | 70 | 66 | |
| MF positive | n (%) | 68 (100%) | 68 (100%) | 70 (100%) | 66 (100%) | |
| MF/mg skin |
Median | 4.5 | 3.3 | 5.2 | 3.6 | |
| 95% CI of the mediana | (2.9–7.6) | (1.4–5.7) | (2.9–8.1) | (1.7–6.2) | ||
| Geometric meanb | 5.2 | 4.5 | 5.7 | 5.5 | ||
| Min–Max | 0.2–69.5 | 0.1–113 | 0.1–367 | 0.1–159 | ||
| 25th; 75th percentiles | 1.2; 14.1 | 0.8; 15.2 | 0.9; 14.8 | 0.9; 10.8 | .77c | |
| 6 months | n | 63 | 66 | 67 | 63 | |
| MF positive | n (%) [95%CI]d | 26 (41.3%) [30–53.6] | 26 (39.4%) [28.5–51.5] | 30 (44.8%) [33.5–56.6] | 18 (28.6%) [18.9–40.7] | .262e |
| MF/mg skin |
Median | 0 | 0 | 0 | 0 | |
| 95% CI of the mediana | (0–.25) | (0–.13) | (0–.29) | (0–0) | ||
| Geometric meanb | 0.25 | 0.25 | 0.35 | 0.19 | ||
| Min–Max | 0–4.2 | 0–4.6 | 0–13.9 | 0–3.3 | ||
| 25th; 75th percentiles | 0; 0.3 | 0; 0.3 | 0; 0.6 | 0; 0.2 | .268c | |
| P Value (comparison to baseline)f | P < .001 | P < .001 | P < .001 | P < .001 | ||
| 18 months | n | 62 | 63 | 64 | 61 | |
| MF positive | n (%) [95%CI]d | 15 (24.2%) [15.2–36.2] | 4 (6.3%) [2.5–15.2] | 12 (18.8%) [11.1–30] | 8 (13.1%) [6.8–23.8] | .035 e |
| MF/mg skin |
Median | 0 | 0 | 0 | 0 | |
| 95% CI of the mediana | (0–0) | (0–0) | (0–0) | (0–0) | ||
| Geometric meanb | 0.09 | 0.02 | 0.11 | 0.06 | ||
| Min–Max | 0–3.7 | 0–0.7 | 0–4.2 | 0–1.6 | ||
| 25th; 75th percentiles | 0; 0 | 0; 0 | 0; 0 | 0; 0 | .051c | |
| P Value (comparison to baseline)f | P < .001 | P < .001 | P < .001 | P < .001 | ||
| 36 months | n | 56 | 59 | 64 | 53 | |
| MF positive | n (%) [95%CI]d | 21 (37.5%) [26–50.6] | 17 (28.8%) [18.8–41.4] | 25 (39.1%) [28.1–51.3] | 10 (18.9%) [10.6–31.4] | .075e |
| MF/mg skin |
Median | 0 | 0 | 0 | 0 | |
| 95% CI of the mediana | (0–0.05) | (0–0) | (0–0.05) | (0–0) | ||
| Geometric meanb | 0.2 | 0.15 | 0.23 | 0.16 | ||
| Min–Max | 0–6.3 | 0–5.6 | 0–11.1 | 0–6.1 | ||
| 25th; 75th percentiles | 0; 0.3 | 0; 0.1 | 0; 0.2 | 0; 0 | .139c | |
| P Value (comparison to baseline)f | P < .001 | P < .001 | P < .001 | P < .001 |
These P-values are written in bold to show the significant values below .05.
Abbreviations: ALB, albendazole; CI, confidence interval; IVM, ivermectin; MF, microfilaria.
aCIs for the median were calculated using bootstrapping.
bThe geometric mean was calculated by adding 1 to the original MF values and subtracting 1 from the final result.
cKruskal-Wallis test.
dCIs for proportions were calculated using the method recommended by Altman et al [30].
eFisher’s exact test.
fWilcoxon signed-rank test.