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. 2019 Sep 20;71(4):971–981. doi: 10.1093/cid/ciz908

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© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Kaplan–Meier analysis of the illness alleviation after treatment with baloxavir marboxil in patients with and without PA/I38T/M-substituted viruses. Influenza illness was composed of cough, nasal discharge/congestion, and body temperature. The median TTIA was 79.6 hours in patients with PA/I38T/M-substituted viruses (n = 18) and was 42.8 hours in patients without PA/I38T/M-substituted viruses (n = 59). Abbreviations: PA/I38T, isoleucine substituted by threonine at position 38 of virus polymerase acidic protein; PA/I38M, isoleucine substituted by methionine at position 38 of virus polymerase acidic protein; TTIA, time to illness alleviation.