Figure 5. .

Kaplan–Meier analysis of the time to sustained cessation of viral shedding by virus titer after treatment with baloxavir marboxil in patients with and without PA/I38T/M-substituted viruses by HAI antibody titer at baseline. Patients with A(H3N2) virus who had paired-sequencing data available were included in this analysis. The median times to sustained cessation of viral shedding: 216.0 hours (antibody <40 with PA/I38T/M-substituted viruses [n = 11]), 24.0 hours (antibody <40 without PA/I38T/M-substituted viruses [n = 15]), 168.0 hours (antibody ≥40 with PA/I38T/M-substituted viruses [n = 7]), and 24.0 hours (antibody ≥40 without PA/I38T/M-substituted viruses [n = 34]). Abbreviations: HAI, hemagglutinin inhibition; PA/I38T, isoleucine substituted by threonine at position 38 of virus polymerase acidic protein; PA/I38M, isoleucine substituted by methionine at position 38 of virus polymerase acidic protein.