TABLE 2.
Clinical characteristics of patients in PCNSL in relation to HIF‐1α, GLUT1, and HK2 protein expression
| Variables | HIF protein expression (n = 39) | HK2 protein expression (n = 39) | GLUT1 protein expression (n = 39) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| + (n = 23) | − (n = 16) | p | + (n = 26) | − (n = 13) | p | + (n = 25) | − (n = 14) | p | |
| Age (years) | |||||||||
| >60 (n = 13) | 8 | 5 | >.05 | 9 | 4 | >.05 | 8 | 5 | >.05 |
| ≤60 (n = 26) | 15 | 11 | 17 | 9 | 17 | 9 | |||
| Gender | |||||||||
| Male (n = 17) | 12 | 5 | >.05 | 12 | 5 | >.05 | 13 | 4 | >.05 |
| Female (n = 22) | 11 | 11 | 14 | 8 | 12 | 10 | |||
| LDH | |||||||||
| Elevated (n = 22) | 17 | 5 | <.05 | 19 | 3 | <.01 | 18 | 4 | <.05 |
| Normal (n = 17) | 6 | 11 | 7 | 10 | 7 | 10 | |||
| No. of lesion | |||||||||
| 1 (n = 25) | 15 | 10 | >.05 | 18 | 7 | >.05 | 15 | 10 | >.05 |
| At least 2 (n = 14) | 8 | 6 | 8 | 6 | 10 | 4 | |||
| ECOG performance status | |||||||||
| 0–1 (n = 12) | 5 | 7 | >.05 | 6 | 6 | >.05 | 5 | 7 | >.05 |
| At least 2 (n = 27) | 18 | 9 | 20 | 7 | 20 | 7 | |||
| Deep structure involvement | |||||||||
| Presence (n = 26) | 17 | 9 | >.05 | 18 | 8 | >.05 | 17 | 9 | >.05 |
| Absence (n = 13) | 6 | 7 | 8 | 5 | 8 | 5 | |||