Coronal PET images showing brain regions with significant (p < .01, K > 50) differences in brain glucose metabolism (BGluM) between home cage (BL) and novel cage (NOV) scans. Red/yellow clusters illustrate BGluM activation, while blue clusters illustrate BGluM inhibition. (a) Lateral orbital cortex (LO), (b) cingulate cortex (Cg), prelimbic cortex (PrL), striatum (CPu), (c) motor cortex (M2), striatum (CPu), (d) motor cortex (M1, M2), cingulate cortex (Cg), insular cortex (Ins), internal capsule (ic), globus pallidus (GP), (e) ventrolateral thalamus (VL), (f) retrosplenial cortex (RSC), striatum (CPu), stria terminalis (st), (g) auditory cortex (Aud), (h) hippocampus (Hipp), visual cortex (V1B, V2L), and (i) inferior colliculus (Colli)