Figure 7.

SNP heritability estimates based on GREML and RNM.

GREML and RNM estimates were derived by fitting a univariate reaction norm model including no interaction term (ie, null model) and one including 1 or more interaction terms (ie, interaction model), respectively. The diagonal is included to highlight the impact of neglecting interaction terms on SNP heritability estimates. Deviations above the diagonal indicate larger RNM estimates relative to GREML estimates. Note HDL2 cholesterol is excluded because of negative variance estimates. ARIC, Atherosclerosis Risk in Communities; BMI, body mass index; GREML, genomic restricted maximum likelihood; HDL, high‐density lipoprotein; RNM, reaction norm models; SNP, single nucleotide polymorphism; and UKBB, UK Biobank.