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. 2020 Apr 16;9(8):e015748. doi: 10.1161/JAHA.119.015748

Figure 2. B7‐33 improves cardiac function 24 hours post MI.

Figure 2

A, Fractional shortening (FS) is preserved in mice treated with B7‐33 (0.25 mg/kg) 24 hours post myocardial infarction (29.57±1.74% vs 23.34±1.84%), compared to vehicle. B, Left ventricular internal diameter (LVID) is significantly elevated in vehicle‐treated mice (3.17±0.13 mm) vs B7‐33–treated mice (2.83±0.11 mm). C, Representative sketches of M‐mode acquisitions and subsequent measurements (bar=1 mm). D, No significant differences in LVID at diastole among the experimental groups (for A‐D, n=9 for sham, and n=14–18 for vehicle and B7‐33 groups). E, Infarct size, expressed as a percentage of risk area, is significantly lower in B7‐33 group (21.99±7.17%; n=7) vs vehicle group (45.32±5.28%; n=8) (bar=3.5 mm). For A, B, and D, 1‐way ANOVA was used to determine significance, and if P<0.05, Holm‐Sidak test was used for post hoc analysis. For E, unpaired T test was used. *P<0.05, ***P<0.001.