Table 2.

Unanswered Questions Regarding TAVR

Questions	Currently Available Data
Should TAVR be used in AR?	Multiple small observational studies demonstrate success with the use of TAVR for AR.60
Should TAVR be used in bicuspid aortic valves?	Observational studies indicate no difference in 1‐y all‐cause mortality.61
Should TAVR be performed in patients with aortic dissection?	Minimal data available.
Should TAVR be performed in prior SAVR prosthetic valves (aka valve‐in‐valve implantation)?	Observational studies indicate that valve‐in‐valve operations have similar outcome to redo SAVR.62
Should TAVR be performed in individuals >90‐y‐old?	Observational study shows worse outcomes than in younger patients.63
Should TAVR be performed in younger populations?	Observational studies show similar or worsened outcomes in younger populations.64, 65
How should obstructive coronary artery disease be treated when a patient is being considered for TAVR?	Numerous studies exist without definitive data, though generally staging PCI and TAVR procedures is the most common strategy.66
Is there a head‐to‐head comparison of clinical outcomes between the different valve manufacturers?	Some evidence suggests that balloon‐expandable TAVRs have better outcomes than self‐expanding TAVR, though there are limitations to the data.35
Should TAVR be performed in patients with end stage renal disease?	Observational studies show worse outcomes.67
Should younger patients receive a mechanical SAVR or a TAVR?	Minimal data available.

AR indicates aortic regurgitation; PCI, percutaneous coronary intervention; SAVR, surgical aortic valve replacement; and TAVR, transcatheter aortic valve replacement.