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. 2020 Apr 19;9(8):e014757. doi: 10.1161/JAHA.119.014757

Figure 3. Spermidine treatment reduces aortic inflammatory cell infiltration and angiogenesis.

Figure 3

Aortic sections from mice 14 days after PPE infusion were stained with antibodies against CD3, CD68, MPO, and CD31. Representative immunostaining images for CD3+ T cells, CD68+ macrophages, MPO + neutrophils, and CD31+ blood vessels. Scale bar=50 μm and 200 μm. Mean and SD of aortic T cells (P=0.001), macrophages (P=0.001), neutrophils (P=0.041), and angiogenesis (P=0.048) quantified as the positive stain cells or vessels per ACS. Unpaired t test, **P<0.01 and *P<0.05 vs vehicle group, n=7 to 12 mice/group. ACS indicates aortic cross section; MPO, myeloperoxidase; and PPE, porcine pancreatic elastase.