Table 3.
Clinical Outcomes of Patients With Deferred Revascularization According to Resistive Reserve Ratio in High FFR or High CFR Subgroups
| High FFR Population | High CFR Population | |||||||
|---|---|---|---|---|---|---|---|---|
| RRR≥3.5 | RRR<3.5 | HR (95% CI) | P Value | RRR≥3.5 | RRR<3.5 | HR (95% CI) | P Value | |
| Per‐patient analysis | 349/643 (54.3%) | 294/643 (45.7%) | 416/597 (69.7%) | 181/597 (30.3%) | ||||
| All‐cause death | 1.3% (4) | 5.0% (11) | 3.483 (1.109–10.94) | 0.023 | 1.7% (6) | 5.3% (7) | 2.857 (0.959–8.502) | 0.048 |
| Cardiac death | 0.6% (2) | 4.2% (9) | 5.709 (1.233–26.44) | 0.012 | 1.1% (4) | 3.3% (4) | 2.460 (0.615–9.839) | 0.188 |
| Myocardial infarction | 1.1% (3) | 1.6% (4) | 1.663 (0.372–7.435) | 0.501 | 1.4% (5) | 0.0% (0) | NA | NA |
| Any revascularization | 4.7% (13) | 10.3% (23) | 2.270 (1.149–4.482) | 0.015 | 5.5% (18) | 8.7% (11) | 1.511 (0.714–3.201) | 0.277 |
| Target vessel‐related revascularizationa | 2.5% (7) | 6.6% (14) | 2.568 (1.036–6.366) | 0.035 | 3.6% (12) | 5.7% (7) | 1.434 (0.565–3.644) | 0.448 |
| Death or myocardial infarction | 2.4% (7) | 6.2% (14) | 2.527 (1.020–6.265) | 0.038 | 2.8% (10) | 5.3% (7) | 1.713 (0.652–4.502) | 0.269 |
| Patient‐oriented composite outcomea | 6.0% (17) | 14.8% (34) | 2.556 (1.428–4.577) | 0.001 | 7.1% (24) | 13.5% (18) | 1.849 (1.003–3.408) | 0.045 |
Data expressed as cumulative incidence of clinical outcomes and numbers of events. Cumulative incidence of clinical outcomes represents Kaplan–Meier estimates during median follow‐up of 1422.0 days (Q1–Q3 566.0–1855.0 days). P values for log‐rank or Breslow test in survival analysis. CFR indicates coronary flow reserve; FFR, fractional flow reserve; HR, hazard ratio; and RRR, resistive reserve ratio.
a
Target vessel‐related revascularization denotes ischemia‐driven revascularization occurred in initially interrogated vessel.