Figure 1. Examples of molecular complexes and proteins of the cardiomyocyte encoded by genes associated with sarcomeric HCM, its mimics and syndromic conditions featuring HCM with different levels of supporting evidence.

Strength of evidence in favor of pathogenicity (top right panel) is coded as in the curation effort by the ClinGen consortium.48 Details about genetic associations for definitive genes displayed in the bottom left and bottom right panel, and genes with ≥ moderate supportive evidence are provided in Tables 1, 2 through 3. HCM, hypertrophic cardiomyopathy.