Figure 2. Number of genes implicated in HCM in the literature with different levels of supporting evidence (black line, left y axis) ranging from fully validated genes (darker green line) to those without substantial evidence supporting pathogenicity.

The black line indicates the number of scientific publications in PubMed featuring next‐generation sequencing (colored lines, right y axis). The classification criteria for evidence in favor of pathogenicity (as detailed in the legend) and the genes included (n=39) reflect the analysis and curation effort by Walsh et al.49 HCM, hypertrophic cardiomyopathy; and NGS, next‐generation sequencing.