Table 1.
Characteristics of Study Population According to Patient‐Management Group
| Not in Patient‐Management Group | Primary Prevention Groups | Secondary Prevention Group | P valuea | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Severe Hypercholesterolemiab | P Valuea | Diabetes Mellitus | P Valuea | Elevated 10‐y Risk of CVD | P Valuea | ||||
| n | 10 261 | 567 | NA | 2277 | NA | 2702 | NA | 2082 | NA |
| Achieve LDL‐C goal (n) | NA | 41 | NA | 1075 | NA | 563 | NA | 337 | NA |
| Age, y, mean (SD) | 50 (7) | 54 (7) | 9×10−26 | 54 (7) | <1×10−100 | 59 (7) | <1×10−100 | 57 (8) | <1×10−100 |
| Women, n (%) | 7553 (74) | 369 (65) | 1×10−5 | 1319 (58) | 6×10−50 | 882 (33) | <1×10−100 | 1140 (55) | 5×10−66 |
| HDL‐C, mg/dL, mean (SD) | 60 (18) | 54 (14) | 9×10−17 | 49 (14) | <1×10−100 | 50 (15) | <1×10−100 | 53 (17) | 4×10−65 |
| LDL‐C, mg/dL, mean (SD) | 110 (28) | 171 (43) | <1×10−100 | 101 (30) | 3×10−37 | 123 (26) | <1×10−100 | 103 (34) | 3×10−18 |
| TC, mg/dL, mean (SD) | 191 (33) | 253 (48) | 3×10−124 | 175 (36) | 1×10−77 | 198 (32) | 2×10−27 | 179 (40) | 3×10−35 |
| Triglycerides, mg/dL, median (IQR) | 93 (69–129) | 134 (99–184) | 3×10−63 | 126 (92–176) | <1×10−100 | 126 (91–178) | <1×10−100 | 111 (79–161) | 7×10−45 |
| CRP, mg/L, mean (SD) | 3.2 (5.3) | 3.5 (4.7) | 0.1 | 5.1 (8.2) | 3×10−25 | 3.5 (4.9) | 2×10−2 | 4.0 (7.7) | 6×10−6 |
| Fasting glucose, mg/dL, mean (SD) | 92 (9) | 104 (36) | 5×10−14 | 137 (51) | <1×10−100 | 97 (10) | <1×10−100 | 108 (36) | 7×10−78 |
| HbA1c, %, mean (SD) | 5.3 (0.3) | 5.7 (1.2) | 5×10−16 | 7.0 (1.5) | <1×10−100 | 5.4 (0.3) | 8×10−87 | 5.9 (1.2) | 2×10−99 |
| SBP, mm Hg, mean (SD) | 120 (14) | 126 (16) | 6×10−16 | 128 (16) | 8×10−96 | 134 (15) | <1×10−100 | 127 (16) | 3×10−69 |
| DBP, mm Hg, mean (SD) | 76 (10) | 77 (11) | 3×10−4 | 78 (10) | 2×10−29 | 81 (10) | <1×10−100 | 76 (10) | 2×10−4 |
| BMI, kg/m2, mean (SD) | 28 (6) | 29 (6) | 0.04 | 33 (8) | <1×10−100 | 30 (6) | 7×10−21 | 30 (7) | 1×10−28 |
| Hypertension, n (%) | 3241 (32) | 250 (44) | 8×10−10 | 1688 (74) | <1×10−100 | 1822 (67) | <1×10−100 | 1475 (71) | <1×10−100 |
| Smoking, n (%) | 816 (8) | 78 (14) | 2×10−6 | 250 (11) | 3×10−6 | 603 (22) | 4×10−100 | 278 (13) | 4x10−15 |
| Diabetes mellitus, n (%) | 0 (0) | 79 (14) | NA | 2277 (100) | NA | 0 (0) | NA | 593 (28) | NA |
| FH of MI, n (%) | 1007 (10) | 65 (11) | 0.2 | 324 (14) | 8×10−10 | 342 (13) | 2×10−5 | 369 (18) | 2x10−25 |
Between‐group differences in continuous variables were assessed by Student t test, except for triglycerides for which Wilcoxon rank sum test was used. Differences in categorical variables were assessed by the χ2 test. Continuous variables are presented as mean (SD), except for triglycerides, which are presented as median (IQR). Categorical variables are summarized by counts (percentage). BMI indicates body mass index; CRP, C‐reactive protein; CVD, cardiovascular disease; DBP, diastolic blood pressure; FH, family history; HbA1C, hemoglobin A1C; HDL‐C, high‐density lipoprotein cholesterol; IQR, interquartile range; LDL‐C, low‐density lipoprotein cholesterol; MI, myocardial infarction; NA, not assessed; SBP, systolic blood pressure; and TC, total cholesterol.
P values are for comparison to the first column (not in patient‐management group).
LDL‐C ≥190 mg/dL at least once in the preceding 5 y.