Table 6.
Cerebral Microdialysis
| Parameter | CA21 | CA100 | Sham |
|---|---|---|---|
| Lactate/pyruvate ratio | |||
| Baseline | 8.99 (1.23) (n=9) | 11.1 (3.81) (n=9) | 9.43 (1.52) (n=3) |
| CPR | 19.3 (2.59) (n=9) | 19.1 (3.35) (n=9) | 10.8 (2.83) (n=4) |
| Post‐ROSC 30 min | 21.0 (1.60) (n=7) | 24.5 (3.59)a (n=8) | 11.3 (3.93) (n=4) |
| Post‐ROSC 1 h | 12.9 (2.88) (n=6) | 14.0 (3.21) (n=8) | 11.3 (2.94) (n=5) |
| Post‐ROSC 2 h | 11.8 (2.56) (n=5) | 7.59 (2.15) (n=6) | 8.12 (0.92) (n=4) |
| Post‐ROSC 3 h | 11.0 (1.28) (n=3) | 10.4 (3.15) (n=5) | 8.23 (3.18) (n=3) |
| Post‐ROSC 4 h | 13.3 (2.83) (n=3) | 12.8 (5.38) (n=2) | 6.22 (2.55) n=3 |
| Glycerol | |||
| Baseline | 19.2 (2.63) (n=9) | 20.2 (2.55) (n=10) | 24.9 (4.90) (n=5) |
| CPR | 24.8 (3.76) (n=8) | 24.6 (2.64) (n=9) | 33.6 (11.8) (n=5) |
| Post‐ROSC 30 min | 80.6 (14.3)a (n=6) | 60.1 (6.61) (n=7) | 29.5 (15.9) (n=5) |
| Post‐ROSC 1 h | 94.0 (13.6) (n=7) | 70.6 (14.1) (n=7) | 38.0 (17.7) (n=5) |
| Post‐ROSC 2 h | 57.1 (9.64) (n=7) | 58.8 (12.8) (n=8) | 33.9 (14.8) (n=5) |
| Post‐ROSC 3 h | 43.3 (10.3) (n=7) | 44.2 (10.5) (n=8) | 36.3 (11.5) (n=5) |
| Post‐ROSC 4 h | 39.9 (14.2) (n=7) | 32.2 (7.83) (n=7) | 42.6 (14.7) (n=4) |
There were no differences in lactate/pyruvate ratio or glycerol between CA21 and CA100 at any time points. Comparisons between groups performed using ANOVA with Bonferroni correction. Values are mean (SEM). CA21 indicates cardiac arrest (CA) with CPR in 0.21 fraction of inspired oxygen (FiO2); CA100, CA with CPR in 1.0 fraction of FiO2; CPR, cardiopulmonary resuscitation; and ROSC, return of spontaneous circulation.
a
P<0.05 compared with sham.