Table 3.

HRs for Subsequent Disease Onset of Incident AF and Incident HF

Variable	HR (95% CI)	P Value
Age (per 5‐y increase)	1.80 (1.66/1.96)	<0.001
Sex (men)	4.41 (3.06/6.36)	<0.001
Body mass index (per 5‐kg/m2 increase)	1.61 (1.49/1.73)	<0.001
Total serum cholesterol (per 1‐mmol/L increase)	1.09 (1.02/1.16)	0.01
Prevalent diabetes mellitus	1.66 (1.27/2.17)	<0.001
Log10(NT‐proBNP) (per 0.3 increase)	1.96 (1.85/2.08)	<0.001

The following variables were also fitted into, but then dropped from, the Cox regression model: cholesterol‐lowering medication, daily consumption of alcohol, systolic blood pressure, heart rate, antihypertensive medication, smoking status, prevalent myocardial infarction, prevalent stroke, hsCRP (high‐sensitivity C‐reactive protein), and estimated glomerular filtration rate. Adjustment for cohort stratification was implemented. After Bonferroni correction to account for multiple testing, a P value threshold of <0.0022 was used. Additional interaction terms were added to improve model fit: age and sex and log10(NT‐proBNP) and time. AF indicates atrial fibrillation; HF, heart failure; HR, hazard ratio; and NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide.