Table 2.

Coefficients From Multivariable Linear Regression Models Estimating the Association Between the Natural Log of mtDNA Heteroplasmy Count and PAD Status by mtDNA Region and Frequency, Adjusting for Age, Sex, Race, and Diabetes Mellitus Status (n=42)

Coefficient	All		All				D‐Loop		Gene Region
			Microheteroplasmy		High Frequency
	β (SE)	P Value	β (SE)	P Value	β (SE)	P Value	β (SE)	P Value	β (SE)	P Value
(Intercept)	2.96 (0.19)	<0.001	2.84 (0.19)	<0.001	0.39 (0.44)	0.387	2.13 (0.22)	<0.001	2.34 (0.23)	<0.001
PAD	0.62 (0.20)	0.003	0.58 (0.19)	0.004	−0.20 (0.45)	0.664	0.49 (0.23)	0.037	0.72 (0.23)	0.004
Agea	0.03 (0.12)	0.815	0.05 (0.12)	0.649	−0.28 (0.27)	0.319	0.01 (0.14)	0.925	0.08 (0.14)	0.581
Men	0.12 (0.16)	0.465	0.09 (0.16)	0.564	0.30 (0.38)	0.427	−0.15 (0.19)	0.445	0.27 (0.19)	0.165
Black	0.15 (0.15)	0.331	0.04 (0.15)	0.785	0.76 (0.35)	0.036	0.14 (0.17)	0.436	0.16 (0.18)	0.387
Diabetes mellitus	−0.27 (0.15)	0.082	−0.23 (0.15)	0.132	−0.05 (0.35)	0.878	−0.25 (0.17)	0.166	−0.38 (0.18)	0.041

D‐loop indicates displacement loop; and PAD, peripheral artery disease.

^aAge centered at 70 years and scaled to 10 years.