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. 2020 Apr 4;9(7):e015154. doi: 10.1161/JAHA.119.015154

Figure 2. Metformin treatment improved cardiac function and normalized cardiac structure in SHR in vivo.

Figure 2

A, Short‐axis CMR images at ED and ES. B, EF, (C) LVM normalized to tibia length (TL), and (D) EDWT measured by CMR for WKY (n=6), SHR (n=6), and SHR treated with metformin (300 mg/kg per day) for 3 months (SHR+M) (n=6). All data are shown as means±SE. CMR indicates cardiac MRI; ED indicates end‐diastole; EF, ejection fraction; EDWT, end‐diastolic wall thickness; ES, end‐systolic; LVM, left ventricular mass; M, metformin; SHR, spontaneously hypertensive rats; WKY, Wistar–Kyoto.