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. 2020 Apr 2;9(7):e014146. doi: 10.1161/JAHA.119.014146

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© 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Knockdown of TMEM106B, but not TMEM100, reverses the effects of knockdown of ANRIL on monocyte adhesion to endothelial cells and transendothelial migration of monocytes.

A, Relative adhesion of monocytes to EA.hy926 cells transiently co‐transfected with different combinations of small interfering (si)NC (negative control siRNA), siANRIL, siTMEM100, or siTMEM106B (n=9 samples/group; 3 wells/experiment with each experiment repeated twice again). B, Relative adhesion of monocytes to human coronary artery endothelial cells transiently co‐transfected with different combinations of siNC, siANRIL, siTMEM100, or siTMEM106B (n=9 samples/group; 3 wells/experiment with each experiment repeated twice again). C, Relative transmigration of monocytes across a layer of EA.hy926 cells transiently co‐transfected with different combinations with siNC, siANRIL, siTMEM100, or siTMEM106B (n=9 samples/group; 3 wells/experiment with each experiment repeated twice again). D, Relative transmigration of monocytes across human coronary artery endothelial cells transiently co‐transfected with different combinations with siNC, siANRIL, siTMEM100, or siTMEM106B (n=9 samples/group; 3 wells/experiment with each experiment repeated twice again). Statistical analysis was performed using unpaired, 2‐tailed Student t‐tests. Si indicates small interfering.