Table 2.
Comparison of histopathologic characteristics of placentas from women after diagnosis of SARS-CoV-2 infection and gestational age–matched historical controls
| Patients with SARS-CoV-2 infection (n=50) | Historical Controls (n=50) | P value | |
|---|---|---|---|
| Placental weight | |||
| <10th percentile | 7 (14) | 10 (20) | .87 |
| 10th–90th percentile | 40 (80) | 37 (74) | |
| >90th percentile | 3 (6) | 3 (6) | |
| Maternal vascular malperfusion | |||
| Accelerated villous maturation | 0 | 1 (2) | 1 |
| Decidual vasculopathy | 0 | 1 (2) | 1 |
| Distal villous hypoplasia | 2 (4) | 1 (2) | 1 |
| Excessive infarction | 4 (8) | 4 (8) | 1 |
| Old hemorrhage in membranes | 1 (2) | 2 (4) | 1 |
| Fetal vascular malperfusion | 4 (8) | 6 (12) | .74 |
| Increased perivillous fibrin | 6 (12) | 7 (14) | 1 |
| Intervillous thrombus | 13 (26) | 8 (16) | .33 |
| Delayed villous maturation | 10 (20) | 13 (26) | .64 |
| Villitis | 2 (4) | 1 (2) | 1 |
| Chorionitis | 11 (22) | 8 (16) | .61 |
| Amnionitis | 9 (18) | 4 (8) | .23 |
| Umbilical vasculitis | 7 (14) | 8 (16) | 1 |
| Retroplacental thrombus | 2 (4) | 0 | .5 |
| Chorangiosis | 3 (6) | 1 (2) | .62 |
| Chorangioma | 0 | 1 (2) | 1 |
| Meconium staining | 9 (18) | 5 (10) | .39 |
Data are presented as number (percentage).
SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
Gulersen et al. Placental histopathologic changes after maternal SARS-CoV-2 infection. AJOG MFM 2020.