Table 4.
Comparison of histopathologic characteristics between placentas from women after diagnosis of SARS-CoV-2 infection who had typical symptoms related to the infection and those without such typical symptoms
| Histopathologic characteristic | Patients with symptoms related to SARS-CoV-2 infection (n=16) | Patients without symptoms related to SARS-CoV-2 infection (n=34) | P value |
|---|---|---|---|
| Placental weight | |||
| <10th percentile | 1 (6.2) | 6 (17.6) | .32 |
| 10th–90th percentile | 13 (81.2) | 27 (79.4) | |
| >90th percentile | 2 (12.5) | 1 (2.9) | |
| Maternal vascular malperfusion | |||
| Distal villous hypoplasia | 0 | 2 (5.9) | 1 |
| Excessive infarction | 3 (18.8) | 1 (2.9) | .09 |
| Old hemorrhage in membranes | 1 (6.2) | 0 | .32 |
| Fetal vascular malperfusion | 1 (6.2) | 3 (8.8) | 1 |
| Increased perivillous fibrin | 2 (12.5) | 4 (11.8) | 1 |
| Intervillous thrombus | 6 (37.5) | 7 (20.6) | .3 |
| Delayed villous maturation | 2 (12.5) | 8 (23.5) | .47 |
| Villitis | 0 | 2 (5.9) | 1 |
| Chorionitis | 2 (12.5) | 9 (26.5) | .47 |
| Amnionitis | 2 (12.5) | 7 (20.6) | .7 |
| Umbilical vasculitis | 2 (12.5) | 5 (14.7) | 1 |
| Retroplacental thrombus | 2 (12.5) | 0 | .1 |
| Chorangiosis | 1 (6.2) | 2 (5.9) | 1 |
| Meconium staining | 4 (25) | 5 (14.7) | .44 |
Data are presented as number (percentage).
SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
Gulersen et al. Placental histopathologic changes after maternal SARS-CoV-2 infection. AJOG MFM 2020.