Table 1.

Surgical Difficulty and Systemic Parameters of Toxicity in rats Submitted to Exodontia of First Lower Molar and Treated With Different Doses of TCZ

	Sham	Saline	TCZ (mg/kg)						P-Value
			1	2	4	8	16	32
Surgical Difficulty
Tooth Mass (mg)	0.0 ± 0.0	16.0 ± 0.6∗	16.1 ± 0.9	15.9 ± 0.8	14.7 ± 0.9	14.5 ± 0.1	15.6 ± 0.8	16.9 ± 1.0	<.001
Radicular Fractures (n)	0.0 ± 0.0	0.6 ± 0.2∗	1.0 ± 0.3	0.8 ± 0.4	1.0 ± 0.4	1.0 ± 0.0	0.7 ± 0.2	0.8 ± 0.3	.043
Ratio final/initial blood cells counting (%)
Withe Blood Cells	124.9 ± 15.0	122.1 ± 6.6	125.9 ± 7.7	109.2 ± 14.6	102.5 ± 4.0	89.2 ± 3.3∗,†	88.7 ± 12.1∗,†	87.7 ± 11.9∗,†	.039
Lymphocytes	124.5 ± 16.8	121.6 ± 6.5	129.7 ± 12.0	110.5 ± 14.8	103.8 ± 3.3	94.0 ± 3.8	98.6 ± 17.1	87.2 ± 15.6	.310
Myeloid cells	125.1 ± 14.0	98.1 ± 12.2	61.6 ± 14.6	74.3 ± 5.1	79.9 ± 10.5	66.9 ± 9.2	34.0 ± 7.1∗,†	29.1 ± 4.9∗,†	<.001
Systemic parameters of toxicity
Body mass (%)	102.7 ± 1.9	105.2 ± 1.1	104.6 ± 1.8	106.7 ± 1.6	105.8 ± 0.8	100.2 ± 1.2	96.60 ± 1.3∗,†	96.40 ± 3.2∗,†	<.001
Liver Index (%)	4.96 ± 0.39	5.34 ± 0.27	5.01 ± 0.23	5.22 ± 0.27	4.81 ± 0.31	4.23 ± 0.22	4.01 ± 0.11†	3.92 ± 0.15∗,†	.001
Spleen Index (%)	0.29 ± 0.05	0.30 ± 0.05	0.29 ± 0.03	0.28 ± 0.03	0.28 ± 0.03	0.28 ± 0.04	0.29 ± 0.06	0.27 ± 0.08	.972
Renal Index (%)	0.47 ± 0.04	0.47 ± 0.01	0.45 ± 0.01	0.49 ± 0.02	0.44 ± 0.02	0.42 ± 0.01	0.48 ± 0.03	0.45 ± 0.02	.420

Organs mass calculated by the ratio between the weight of each organ and weight of rat on euthanasia day.

Body mass variation calculated by the ratio between final/initial weight. Bold values indicate significant P-values.

Abbreviation: TCZ, Tocilizumab.

^∗P < .5 versus Sham group.

^†P < .5 versus saline group.