Table 3.
Summary of the alleles found in the studied patients indicating their frequency in Spain and in each group of patients.
| Allele | Hla supertype | Freq Spain | Presence in severe grouP (n = 40 alleles; 20 patients) | Freq. in severe group | Presence in moderate group (n = 40 alleles; 20 patients) | Freq. in moderate group | Presence in mild group (n = 10 alleles; 5 patients) | Freq. in mild group | N° loosely binding peptides (<500 nm) | N° tightly binding peptides (<50 nm) |
|---|---|---|---|---|---|---|---|---|---|---|
| A*01:01 | A01 | 0,1 | 10 | 0,25 | 4 | 0,1 | 0 | 0 | 139 | 44 |
| A*02:01 | A02 | 0,25 | 5 | 0,125 | 6 | 0,15 | 4 | 0,4 | 795 | 267 |
| A*02:05 | A02 | 0,01 | 2 | 0,05 | 0 | 0 | 2 | 0,2 | 817 | 158 |
| A*03:01 | A03 | 0,06 | 6 | 0,15 | 6 | 0,15 | 1 | 0,1 | 409 | 73 |
| A*11:01 | A03 | 0,05 | 2 | 0,05 | 6 | 0,15 | 1 | 0,1 | 582 | 168 |
| A*23:01 | A24 | 0,03 | 1 | 0,025 | 1 | 0,025 | 0 | 0 | 418 | 82 |
| A*24:02 | A24 | 0,07 | 6 | 0,15 | 3 | 0,075 | 0 | 0 | 286 | 43 |
| A*25:01 | A01 | 0,01 | 0 | 0 | 2 | 0,05 | 0 | 0 | 19 | 1 |
| A*26:01 | A01 | 0,03 | 0 | 0 | 3 | 0,075 | 0 | 0 | 84 | 10 |
| A*29:02 | A01 A24 | 0,05 | 2 | 0,05 | 1 | 0,025 | 1 | 0,1 | 445 | 112 |
| A*31:01 | A03 | 0,03 | 0 | 0 | 2 | 0,05 | 0 | 0 | 494 | 107 |
| A*32:01 | A01 | 0,03 | 2 | 0,05 | 1 | 0,025 | 0 | 0 | 242 | 42 |
| A*33:03 | A03 | 0,01 | 0 | 0 | 0 | 0 | 1 | 0,1 | 312 | 61 |
| A*66:01 | A03 | 0,02 | 0 | 0 | 1 | 0,025 | 0 | 0 | 69 | 2 |
| A*68:01 | A03 | 0,02 | 0 | 0 | 1 | 0,025 | 0 | 0 | 604 | 217 |
| A*68:02 | A02 | 0,01 | 0 | 0 | 1 | 0,025 | 0 | 0 | 612 | 164 |
| B*07:02 | B07 | 0,05 | 4 | 0,1 | 4 | 0,1 | 0 | 0 | 158 | 36 |
| B*07:05 | B07 | 0,01 | 1 | 0,025 | 0 | 0 | 0 | 0 | 175 | 46 |
| B*08:01 | B08 | 0,06 | 5 | 0,125 | 3 | 0,075 | 0 | 0 | 200 | 25 |
| B*13:02 | B62 | 0,01 | 1 | 0,025 | 0 | 0 | 0 | 0 | 28 | 0 |
| B*14:02 | B27 | 0,04 | 1 | 0,025 | 1 | 0,025 | 0 | 0 | 13 | 1 |
| B*15:01 | B62 | 0,02 | 0 | 0 | 0 | 0 | 2 | 0,2 | 616 | 123 |
| B*15:02 | B62 | 0,01 | 0 | 0 | 2 | 0,05 | 0 | 0 | 295 | 40 |
| B*15:03 | B27 | 0,01 | 0 | 0 | 0 | 0 | 2 | 0,2 | 1236 | 373 |
| B*18:01 | B44 | 0,06 | 2 | 0,05 | 2 | 0,05 | 1 | 0,1 | 89 | 12 |
| B*27:02 | B27 | 0,01 | 1 | 0,025 | 1 | 0,025 | 0 | 0 | 38 | 1 |
| B*27:05 | B27 | 0,02 | 1 | 0,025 | 2 | 0,05 | 1 | 0,1 | 203 | 22 |
| B*35:01 | B07 | 0,04 | 0 | 0 | 3 | 0,075 | 0 | 0 | 294 | 104 |
| B*35:03 | B07 | 0,03 | 2 | 0,05 | 2 | 0,05 | 0 | 0 | 26 | 2 |
| B*35:08 | B07 | 0,01 | 0 | 0 | 1 | 0,025 | 0 | 0 | 119 | 14 |
| B*38:01 | B27 | 0,02 | 0 | 0 | 2 | 0,05 | 0 | 0 | 41 | 1 |
| B*39:01 | B27 | 0,01 | 1 | 0,025 | 2 | 0,05 | 0 | 0 | 122 | 23 |
| B*39:06 | B27 | 0,01 | 2 | 0,05 | 0 | 0 | 0 | 0 | 70 | 6 |
| B*40:01 | B44 | 0,04 | 1 | 0,025 | 1 | 0,025 | 0 | 0 | 156 | 38 |
| B*40:02 | B44 | 0,03 | 1 | 0,025 | 0 | 0 | 1 | 0,1 | 297 | 57 |
| B*40:06 | B44 | 0,02 | 0 | 0 | 1 | 0,025 | 0 | 0 | 1054 | 6 |
| B*44:02 | B44 | 0,04 | 2 | 0,05 | 2 | 0,05 | 1 | 0,1 | 116 | 19 |
| B*44:03 | B44 | 0,06 | 2 | 0,05 | 1 | 0,025 | 1 | 0,1 | 115 | 22 |
| B*47:01 | B44 | 0 | 1 | 0,025 | 0 | 0 | 0 | 0 | 74 | 1 |
| B*48:01 | B27 | 0 | 1 | 0,025 | 0 | 0 | 0 | 0 | 18 | 1 |
| B*49:01 | XXX | 0,04 | 1 | 0,025 | 2 | 0,05 | 0 | 0 | 49 | 4 |
| B*50:01 | B44 | 0,02 | 1 | 0,025 | 2 | 0,05 | 1 | 0,1 | 188 | 13 |
| B*51:01 | B07 | 0,06 | 1 | 0,025 | 3 | 0,075 | 0 | 0 | 33 | 1 |
| B*51:02 | B07 | 0 | 1 | 0,025 | 0 | 0 | 0 | 0 | 48 | 2 |
| B*52:01 | B62 | 0,03 | 2 | 0,05 | 0 | 0 | 0 | 0 | 4 | 0 |
| B*53:01 | B07 | 0,01 | 1 | 0,025 | 0 | 0 | 0 | 0 | 152 | 32 |
| B*55:01 | B07 | 0,02 | 0 | 0 | 2 | 0,05 | 0 | 0 | 53 | 7 |
| B*57:01 | B58 | 0,03 | 2 | 0,05 | 0 | 0 | 0 | 0 | 225 | 38 |
| B*58:02 | B58 | 0,01 | 1 | 0,025 | 0 | 0 | 0 | 0 | 7 | 0 |
| C*01:02 | C1 | 0,03 | 1 | 0,025 | 4 | 0,1 | 1 | 0,1 | 4 | 0 |
| C*02:02 | C2 | 0,04 | 2 | 0,05 | 2 | 0,05 | 1 | 0,1 | 153 | 2 |
| C*03:03 | C1 | 0,04 | 0 | 0 | 1 | 0,025 | 1 | 0,1 | 284 | 86 |
| C*03:04 | C1 | 0,03 | 1 | 0,025 | 2 | 0,05 | 0 | 0 | 284 | 86 |
| C*04:01 | C2 | 0,1 | 2 | 0,05 | 5 | 0,125 | 0 | 0 | 6 | 0 |
| C*05:01 | C2 | 0,09 | 3 | 0,075 | 3 | 0,075 | 1 | 0,1 | 60 | 16 |
| C*06:02 | C2 | 0,07 | 3 | 0,075 | 1 | 0,025 | 1 | 0,1 | 44 | 6 |
| C*07:01 | C1 | 0,13 | 9 | 0,225 | 5 | 0,125 | 0 | 0 | 40 | 4 |
| C*07:02 | C1 | 0,06 | 8 | 0,2 | 8 | 0,2 | 0 | 0 | 115 | 8 |
| C*08:01 | C1 | 0 | 1 | 0,025 | 1 | 0,025 | 0 | 0 | 79 | 4 |
| C*08:02 | C1 | 0,07 | 1 | 0,025 | 1 | 0,025 | 0 | 0 | 24 | 2 |
| C*12:02 | C1 | 0,02 | 2 | 0,05 | 1 | 0,025 | 0 | 0 | 271 | 26 |
| C*12:03 | C1 | 0,07 | 1 | 0,025 | 2 | 0,05 | 1 | 0,1 | 569 | 94 |
| C*15:02 | C2 | 0,04 | 1 | 0,025 | 1 | 0,025 | 0 | 0 | 193 | 16 |
| C*15:05 | C2 | 0,01 | 0 | 0 | 0 | 0 | 0 | 0 | 118 | 5 |
| C*16:01 | C1 | 0,07 | 2 | 0,05 | 2 | 0,05 | 1 | 0,1 | 472 | 66 |
| C*17:01 | C2 | 0,02 | 0 | 0 | 0 | 0 | 1 | 0,1 | 55 | 3 |
Note that each patient has two alleles from each locus, so the total number of alleles in each group has been used for calculating frequencies and not the number of patients. Consequently, the groups with 20 patients include 40 alleles, while the group with 5 includes 10 alleles. For each one, the HLA supertype as well as the number of SARS-CoV-2 peptides recognized with loosely (<500 nm) and tightly (<50 nm) high and low affinity according to Nguyen et al. (11) is also indicated.