Table 3.

Correlation between clinicopathological factors and p53 expression

Clinicopathological parameter		Number (n = 266)	aP53 nuclear expression (n = 266)			aP value	bTP53 gene status (n = 266)		bP value
			negative (n = 40)	10%-50%(n = 69)	> 50% (n = 157)		Wild type(n = 176)	Mutated (n = 90)
Age (yr)	≤ 60	96	15	28	53	> 0.05	70	26	> 0.05
	> 60	170	25	41	104		106	64
Localization	Proximal/middle	155	22	34	99	> 0.05	95	60	0.05
	Distal and antrum	95	15	33	47		72	23
	Diffuse localization	16	3	3	10		9	7
Microscopy	G1+2	75	9	20	46	> 0.05	43	32	> 0.05
	G3	76	14	23	39		51	25
	Papillary	10	1	2	7		5	5
	Poorly cohesive	53	5	14	34		35	18
	Signet ring cell	25	8	2	15		19	6
	Micro-glandular	27	3	8	16		23	4
Budding degree (Dyscohesivity)	Nodular	34	4	8	22	> 0.05	17	17	0.05
	≤ 5 buds/HPF	17	2	7	8		9	8
	5-9 buds/HPF	50	5	19	26		30	20
	≥ 10 buds/HPF	60	11	13	36		42	18
	Diffuse	105	18	22	65		78	27
pT stage	pT1,2	37	6	7	24	> 0.05	24	13	> 0.05
	pT3,4	229	34	62	133		152	77
pN stage	pN0	53	11	13	29	> 0.05	32	21	> 0.05
	pN1-3	213	29	56	128		144	69
Dukes-MAC-like stage	1 + 3 - T1,2N0	17	2	3	12	> 0.05	12	5	> 0.05
	2 + 4 - T1,2N1-3	20	3	3	14		11	9
	5 + 7 – T3,4N0	36	7	10	19		20	16
	6 + 8 – T3,4N1-3	193	28	53	112		133	60

G1: Well differentiated, G2: Moderately differentiated, G3: Poorly differentiated; pT: Depth of tumor infiltration; pN: Lymph node status.