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. 2020 Jul 15;12(7):705–718. doi: 10.4251/wjgo.v12.i7.705

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Immunohistochemical staining (400 ×). A and B: Immunohistochemical positivity for chromogranin A (A) or synaptophysin (B) is considered to be a marker for neuroendocrine neoplasms. Mitotic figures rating [G3 26/10 high-power field (HPF)] is higher than the Ki67 index rating (G2, 16%); C and D: Four mitoses in one HPF is shown by black arrows (C) and related Ki67 immunohistochemical staining is shown in D; E and F: Hemtoxylin and eosin (H&E) staining of well-differentiated pancreatic neuroendocrine tumor G3 (E) and related Ki67 immunohistochemical staining (F); G and H: H&E staining of poorly differentiated pancreatic neuroendocrine carcinoma (G) and related Ki-67 immunohistochemical staining (H).