TABLE 2.
Relative liver weight (%) and liver function in guinea pigs after the GPMT challenged with TCE, TCA, and TCEOH
| Group | Relative Liver weight (%) | Liver functions | |||||
|---|---|---|---|---|---|---|---|
| Number of guinea pigs (n) | Body weight (g) | Liver (g) | Ratio % | Number of guinea pigs (n) | ALT | γ‐GTP | |
| Blank | 5 | 421.17 ± 27.69 | 15.86 ± 1.57 | 3.78 ± 0.56 | — | — | |
| DNCB | 5 | 370.96 ± 26.37 | 13.74 ± 2.09 | 3.69 ± 0.31 | — | — | — |
| TCE solvent control | 5 | 402.04 ± 27.01 | 14.37 ± 1.10 | 3.58 ± 0.31 | 5 | 38.78 ± 4.21 | 12.80 ± 3.42 |
| TCEOH solvent control | 5 | 340.56 ± 40.12 | 11.96 ± 1.67 | 3.51 ± 0.29 | 5 | 40.04 ± 12.87 | 13.20 ± 6.10 |
| TCA solvent control | 5 | 319.88 ± 27.31 | 15.53 ± 1.70 | 3.91 ± 0.29 | 5 | 41.60 ± 11.97 | 14.25 ± 2.06 |
| TCE | |||||||
| dermatitis (‐) | 1 | 352.8 | 14.07 | 3.99 | 1 | 41 | 27 |
| dermatitis (+) | 9 | 378.72 ± 17.66 | 13.90 ± 2.18 | 3.66 ± 0.53 | 9 | 56.40 ± 14.52 a | 26.00 ± 7.14 a |
| TCEOH | |||||||
| dermatitis (‐) | 5 | 288.46 ± 20.33 | 10.32 ± 0.91 | 3.58 ± 0.24 | 4 | 41.50 ± 12.87 | 16.00 ± 4.08 |
| dermatitis (+) | 5 | 336.90 ± 35.61 | 11.64 ± 2.24 | 3.47 ± 0.61 | 4 | 52.75 ± 1.50 b , c | 21.17 ± 4.50 b , c |
| TCA | |||||||
| dermatitis (‐) | 10 | 344.31 ± 25.06 | 11.01 ± 0.87 | 3.56 ± 0.41 | 8 | 45.13 ± 9.72 | 14.13 ± 5.33 |
| dermatitis (+) | 0 | — | — | — | — | — | — |
DNCB, 2,4‐dinitrochlorobenzene; GPMT, guinea pig maximization test; TCA, trichloroacetic acid; TCE, trichloroethylene; TCEOH; trichloroethanol.
a
P < .05, compared to the TCE solvent control group.
b
P < .05, compared to the TCEOH solvent control group.
c
P < .05, compared to the TCEOH dermatitis‐negative group.