TABLE 1.

Summary of the five hypotheses tested for their ability to resolve Peto's paradox

	Hypothesis	Parameter change	Reference equations
Intrinsic effect of size
Metabolic rate change	MR: Lower somatic mutation rate and/or slower cell division	uk ↓	Equations 1, 4, 7, 8
Adaptation in response to size and/or longevity
Suppression	Increased genetic suppression (more driver mutations)	M ↑	1, 2
	Decreased somatic mutation rate	u ↓	1, 2
Immune policing	Increased detection of cancer cells	ec ↑	5
	Increased detection of cells with driver mutations	ed ↑	6