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. Author manuscript; available in PMC: 2020 Aug 16.
Published in final edited form as: J Invest Dermatol. 2017 Dec 27;138(6):1391–1399. doi: 10.1016/j.jid.2017.12.025

Figure 6. Cooling inhibits chronic itch.

Figure 6.

(a) A chronic itch model of dry skin (acetone, ether, and water [AEW]) was induced by twice daily treatments with an acetone/ether/water treatment protocol for 15 days. At 30°C, spontaneous hind-paw behaviors observed in the treated hind paw (ipsilateral) were significantly different than those in the untreated paw (contralateral, ***P < 0.001, one-way ANOVA, Neuman-Keuls post-test, n = 10), and inhibited when the plate was cooled to 20°C (***P < 0.001, one-way ANOVA, Neuman-Keuls post-test, n = 10). At 20°C, there was no significant difference between the ipsilateral and contralateral paws (nsP > 0.05, one-way ANOVA, Neuman-Keuls post-test, n = 10). (b) Control, water alone–treated hind paws displayed no significant difference in spontaneous behaviors at either temperature (nsP > 0.05, one-way ANOVA, Neuman-Keuls post-test, n = 6).