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. 2020 Aug 7;2020:4952372. doi: 10.1155/2020/4952372

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Copyright © 2020 Adrienn Kis et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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In vivo PET/MRI studies of α_vβ₃ integrin receptor expression in subcutaneously transplanted He/De tumors. Representative coronal (a) and axial (b, c) PET/MRI images of subcutaneously transplanted He/De tumors 13 days after tumor induction and 90 min after intravenous injection of ⁶⁸Ga-NODAGA-[c(RGD)]₂. White arrows: α_vβ₃ integrin receptor positive (avid) regions; yellow arrows: nonavid regions. (d) Quantitative PET/MRI image analysis of heterogenous He/De (n = 15) tumors. Significance levels: p ≤ 0.05 (∗) and p ≤ 0.01 (∗∗). Data is presented as the mean ± SD.