Figure 4.

In vivo PET/MRI image analysis of hypoxia regions and CD13 expression in relation to tumor volume enlargement in subcutaneously transplanted He/De tumors. Representative axial PET/MRI images of subcutaneously transplanted He/De tumor-bearing rats 90 min after intravenous injection of ⁶⁸Ga-DOTA-nitroimidazole (a, c, e) and ⁶⁸Ga-NOTA-c(NGR) (b, d, f). Quantitative analysis of PET/MRI images of He/De tumors using ⁶⁸Ga-NOTA-c(NGR) (g) and ⁶⁸Ga-DOTA-nitroimidazole (h) in correlation with tumor volume enlargement and relation between ⁶⁸Ga-NOTA-c(NGR) and ⁶⁸Ga-DOTA-nitroimidazole during tumor growth (i). Data is presented as the mean ± SD.