Table 3.
Summary of adverse events.
| References | Details of adverse events |
| Ahmad et al (2018) [59] | “No adverse events or unintended adverse consequences of the intervention were reported by the participants.” |
| Armstrong et al (2017) [68] | “We observed no adverse events associated with participation in the text message intervention.” |
| Bul et al (2016) [65] | “There were 10 adverse events that could be related to the intervention... All adverse events were of mild (n=5) or moderate (n=5) severity… Examples of adverse events were pain in the fingers, irritability, and headache. An adverse event was a reason to discontinue the study for only one known participant. This participant did not want to play the game anymore because he could not concentrate during his school activities. Sounds reminded him of the game and this consequently distracted and frustrated him. No serious adverse events were reported.” |
| Burckhardt et al (2018) [71] | Did not capture adverse events. |
| Christison et al (2016) [69] | Did not capture adverse events. |
| Fiks et al (2015) [72] | Did not capture adverse events. |
| Hamilton-Shield et al (2014) [73] | “There were no adverse events regarded as serious, unexpected or suspected to be related to the study treatment” |
| Hsieh et al (2018) [66] | Methods: “no adverse effects were expected in participants in the intervention group.” No further details of adverse effects were reported. |
| Jolstedt et al (2018) [60] | “No severe adverse events were reported in either group... The number of adverse events was similar between the groups.” Total reported adverse events: ICBTa 17 (26%), ICDP (active control) 16 (25%). |
| Kassee et al (2017) [74] | Did not capture adverse events. |
| Preston et al (2016) [75] | “No adverse events were reported.” |
| Price et al (2015) [76] | Did not capture adverse events. |
| Sanchez et al (2017) [70] | Did not capture adverse events. |
| Staiano et al (2018) [61] | “Among those randomized to the intervention group, two children reported an injury during gameplay (bruise to the ankle or wrist).” “Two adverse events (bruising) were reported in the GameSquad trial, which is similar to prior exergaming studies reporting minor bruises, hand lacerations and back pain ...” |
| Trost et al (2018) [62] | Did not capture adverse events. |
| Vigerland et al (2016) [63] and Vigerland et al (2017) [64] | Did not capture adverse events. |
| Wantanakorn et al (2018) [67] | Did not capture adverse events. |
aICBT: internet-delivered cognitive behavioral therapy.