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. 2020 Jun 9;9(11):e014199. doi: 10.1161/JAHA.119.014199

Figure 2. In vitro characterization of burst pressure and adhesive strength of gelatin methacryloyl (GelMA) bioadhesive hydrogel.

Figure 2

A, Burst pressure test on explanted rat hearts treated with GelMA bioadhesive (n=6) and the commercially available sealant Coseal (n=6). (i) Schematic of the modified standard test method for burst pressure, (ii) representative images of rat hearts before and after applying air pressure, and (iii) average burst pressure of GelMA hydrogels (10% [w/v]) compared with Coseal and a pristine heart. B, Wound closure test to measure the adhesive strength on isolated rat hearts treated with GelMA bioadhesive (n=6) and Coseal (n=6). (i) Schematic of the modified standard test method for wound closure, (ii) representative images of the wound closure test on samples from rat ventricles using GelMA and Coseal, and (iii) adhesive strength of GelMA hydrogels (10% [w/v]) compared with Coseal. C, Representative scanning electron micrographs from the interface between the ventricular myocardium and the GelMA hydrogels. Data are shown as mean±SD. P values were determined by 1‐way ANOVA, followed by Tukey's multiple comparisons test, for A and B. LV indicates left ventricle.