Table 5.
Global and Regional Brain Volumes for CHD and Control Participants
| Variable | ASD (n=33) | VSD (n=30) | CHD (n=63) | Control (n=38) | P Value, ASD Vs VSD | P Value, All CHD Vs Control |
|---|---|---|---|---|---|---|
| Global | ||||||
| Total intracranial volume, cm3 | 1342.9±126.3 | 1372.2±133.9 | 1357.4±129.7 | 1400.4±141.2 | 0.392 | 0.122 |
| Grey matter, cm3 | 788.3±32.9 | 784.6±49.3 | 786.6±41.2 | 771.7±51.0 | 0.726 | 0.112 |
| White matter, cm3 | 434.6±27.7 | 428.1±26.6 | 431.5±27.2 | 437.8±26.8 | 0.260 | 0.349 |
| Corpus callosum, cm2 | 6.0±1.0 | 6.0±0.7 | 5.9±0.8 | 6.2±0.8 | 0.613 | 0.113 |
| Cerebellum, cm3 | 134.2±8.3 | 135.6±11.1 | 134.9±9.7 | 132.4±8.9 | 0.595 | 0.206 |
| Lobes | ||||||
| Frontal right, cm3 | 212.8±10.3 | 207.1±8.5 | 210.1±9.8 | 208.4±10.2 | 0.020 | 0.404 |
| Frontal left, cm3 | 210.2±9.5 | 204.4±8.8 | 207.4±9.5 | 206.7±9.9 | 0.016 | 0.711 |
| Parietal right, cm3 | 102.7±6.4 | 101.5±5.7 | 102.2±6.0 | 103.8±7.1 | 0.434 | 0.237 |
| Parietal left, cm3 | 101.9±6.0 | 101.3±6.6 | 101.6±6.3 | 101.4±7.3 | 0.682 | 0.850 |
| Temporal right, cm3 | 126.2±4.7 | 126.6±7.9 | 126.4±6.4 | 126.2±5.7 | 0.821 | 0.866 |
| Temporal left, cm3 | 121.0±4.9 | 121.9±6.6 | 121.4±5.8 | 121.1±6.2 | 0.538 | 0.841 |
| Occipital right, cm3 | 56.6±4.3 | 57.8±5.5 | 57.2±4.9 | 54.5±5.5 | 0.330 | 0.012 |
| Occipital left, cm3 | 53.7±4.2 | 53.7±5.7 | 53.7±4.9 | 52.9±4.9 | 0.973 | 0.456 |
| Basal nuclei | ||||||
| Thalami, cm3 | 12.6±1.0 | 12.5±0.8 | 12.6±0.9 | 12.7±0.8 | 0.912 | 0.523 |
| Putamen, cm3 | 10.8±8.5 | 11.1±9.4 | 10.9±9.0 | 10.7±9.7 | 0.218 | 0.177 |
| Nucleus Caudate, cm3 | 11.8±9.6 | 11.7±8.3 | 11.8±0.9 | 11.7±0.9 | 0.535 | 0.551 |
| Limbic lobes | ||||||
| Hippocampi, cm3 | 6.0±0.7 | 5.9±0.5 | 5.9±0.6 | 5.9±0.6 | 0.492 | 0.622 |
| Ventricles | ||||||
| Lateral ventricles, cm3 | 15.3±5.9 | 15.2±6.6 | 15.2±6.2 | 13.6±5.6 | 0.938 | 0.184 |
Data are presented as mean±SD. ASD, atrial septal defect; CHD, congenital heart defect; and VSD, ventricular septal defect.