Skip to main content
. 2020 Jun 9;9(12):e015222. doi: 10.1161/JAHA.119.015222

Figure 2. Cardiospecific overexpression of ATPGD1 (carnosine synthase) increases histidyl dipeptide levels and protects against ischemia reperfusion injury.

Figure 2

A, Representative Western blot of ATPGD1 in wild‐type (WT) and ATPGD1‐transgenic (Tg) hearts (i); lower panel represents the band intensity normalized to tubulin between the 2 groups (ii); n=4 in each group. B, Fold changes in carnosine and anserine levels in WT and ATPGD1‐Tg hearts, n=4 in each group. C, Representative images of 2,3,5‐triphenyl tetrazolium chloride–stained WT and ATPGD1‐Tg hearts after 30 minutes of ischemia followed by 24 hours of reperfusion. D and E, Quantification of the ratio of area of risk (AAR) and left ventricle (LV) and the ratio of infarct size (IF) and AAR in the WT (n=6) and ATPGD1‐Tg (n=7) hearts. Results are mean±SEM. *P<0.05 vs WT mice hearts.