Table 2.

HRs for Stroke

	Group 1 No AF, No Comorbidities n=7837 (27.7%)	Group 2 No AF, Has Comorbidities n=18 103 (64.1%)	Group 3 Has AF, No Comorbidities n=386 (1.4%)	Group 4 Has AF, Has Comorbidities n=1927 (6.8%)
Strokes	175	867	18	146
Total follow‐up, person‐y	72 900	153 578	3330	14 752
Stroke incidence rate (per 1000 person‐y)	2.4	5.6	5.4	9.9
Unadjusted HR	1.0 (reference)	2.34 (1.99–2.76)	2.24 (1.33–3.54)	4.08 (3.27–5.08)
Model 1	1.0 (reference)	1.79 (1.50–2.14)	1.55 (0.84–2.62)	2.79 (2.20–3.54)
Model 2	1.0 (reference)	1.83 (1.53–2.20)	1.38 (0.70–2.42)	2.91 (2.27–3.73)
Model 3	1.0 (reference)	1.77 (1.48–2.14)	1.23 (0.62–2.18)	2.52 (1.93–3.28)

Model 1 adjusts for age, sex, race, education, income, and geographic region. Model 2 adjusts for the covariates in model 1, with the addition of high‐density lipoprotein cholesterol, total cholesterol, body mass index, and smoking. Model 3 adjusts for the covariates in model 2, with the addition of regular aspirin use and warfarin use. Raw incidence rates and multivariable‐adjusted hazard ratios (HRs) for stroke in groups based on the presence or absence of atrial fibrillation (AF) and the presence or absence of cardiovascular comorbidities are provided. After adjustment for covariates, the hazard for stroke was not significantly elevated in group 3 (patinets with AF without comorbidities).