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. 2020 Jun 1;9(12):e015513. doi: 10.1161/JAHA.119.015513

Figure 6. Tranilast (TR) represses the initiation of atherosclerosis in apolipoprotein E–deficient (ApoE−/−) mice (group 3).

Figure 6

A, Illustrated is the regimen for treatment of ApoE−/− mice (6 to 8 weeks old) with TR (n=8) or vehicle (n=9). The atherosclerotic lesions (B through D), the collagen content in the plaque (E), the fibrous caps and the necrotic core (F), the expression of the indicated proteins (G through I), and the profile of the plasma lipids and lipoproteins (J) in mice were evaluated and quantified as described in Figure 3. *P<0.05; **P<0.01; ***P<0.001.