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. 2020 Aug 11;11(32):3048–3060. doi: 10.18632/oncotarget.27694

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Copyright: Mainetti et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Tumor growth assessment: data for each time-point in mm³ are mean ± SEM. (A) M-234p, N = 6/group; Day 21: Control (600.96 ± 93) vs Cy+Los (20.96 ± 9.01) (P < 0.05); (B) M-406, N = 6–7/group; Day 17: Control (1397.00 ± 328.32) vs Cy (372.00 ± 55.25) (P < 0.01), vs Los (451.07 ± 143.94) (P < 0.05), vs Cy+Los (123.43 ± 45.71) (P < 0.001). Kruskal-Wallis multiple comparison test and Dunn’s post-test. Overall survival (Kaplan-Meier), Median Survival (MS): (C) M-234p, N = 5–6/group; Control (MS: 34 days); Cy (MS: 47 days); Los (MS: 32 days); Cy+Los (MS: undefined, Day 32: 60% [3/5] complete tumor regressions). Cy+Los vs Control, vs Los, vs Cy (P < 0.01); (D) M-406, N = 6–7/group); Control (MS: 24 days); Cy (MS: 36.5 days); Los (MS: 33 days); Cy+Los (MS: 47 days). Control vs Cy (P < 0.01), vs Los (P < 0.01), vs Cy+Los (P < 0.001); Cy+Los vs Cy (P < 0.05), vs Los (P < 0,001). Log-rank Test.