Table 2.
Baseline | Visit 2 | Visit 3 | Visit 2 vs Baseline | Visit 3 vs Baseline | |||||
---|---|---|---|---|---|---|---|---|---|
Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | p | d | Median (IQR) | p | d | |
MSBR group, n=12 | |||||||||
Memory score | 0.01 (−0.89–0.32) | 0.07 (−0.64–0.32) | 0.05 (−0.65–0.32) | −0.06 (−0.35–0.3) | 1 | −0.103 | −0.21 (−0.33–0.22) | 1 | −0.521 |
Executive functions | −0.05 (−0.3–0.38) | 0.11 (−0.51–0.38) | 0.01 (−0.4–0.38) | −0.08 (−0.44–0.15) | 1 | −0.182 | −0.11 (−0.26–0.42) | 1 | −0.191 |
Cogstate DET | 2.56 (2.52–2.68) | 2.53 (2.48–2.68) | 2.54 (2.48–2.68) | −0.04 (−0.07 – −0.02) | 0.178 | −0.685 | −0.03 (−0.08–0.02) | 0.883 | −0.306 |
Cogstate IDN | 2.76 (2.71–2.81) | 2.72 (2.71–2.81) | 2.75 (2.73–2.81) | −0.02 (−0.04–0.01) | 0.647 | −0.53 | −0.02 (−0.05–0.01) | 1 | −0.312 |
Cogstate OCL | 0.93 (0.86–1.04) | 0.93 (0.86–1.04) | 0.91 (0.82–1.04) | −0.01 (−0.04–0.07) | 1 | −0.114 | −0.04 (−0.11–0.02) | 1 | −0.38 |
Cogstate ONB | 1.27 (1.15–1.39) | 1.23 (1.07–1.39) | 1.26 (1.11–1.39) | 0 (−0.09–0.11) | 1 | 0 | 0 (−0.08–0.05) | 1 | 0 |
GDS | 5.5 (4.5–8.25) | 3 (1–8.25) | 2.5 (1–8.25) | −3.5 (−4.25 – −1.75) | 0.03 | −1.398 | −2 (−5.25 – −1) | 0.046 | −0.559 |
BAI | 11 (8.25–17.5) | 10.5 (4–17.5) | 11 (7.25–17.5) | −1.5 (−10 – 4.25) | 1 | −0.147 | −1.5 (−5 – 2.75) | 1 | −0.141 |
Control group, n=8 | |||||||||
Memory score | 0.24 (−0.74–0.82) | 0.25 (−0.32–1.29) | 0.45 (−0.57–0.97) | 0.03 (−0.65–0.74) | 1 | 0.034 | 0.1 (−0.08–0.5) | 0.834 | 0.156 |
Executive functions | −0.32 (−0.4–0.08) | 0 (−0.22–0.19) | −0.28 (−0.35 – −0.09) | 0.18 (−0.23–0.66) | 1 | 0.286 | −0.02 (−0.28–0.05) | 0.834 | −0.061 |
Cogstate DET | 2.52 (2.46–2.58) | 2.53 (2.52–2.64) | 2.52 (2.47–2.6) | 0.04 (0–0.08) | 0.560 | 0.72 | −0.01 (−0.04–0.07) | 0.834 | −0.200 |
Cogstate IDN | 2.74 (2.69–2.75) | 2.71 (2.7–2.75) | 2.73 (2.71–2.75) | 0.01 (−0.04–0.02) | 1 | 0.112 | −0.01 (−0.02–0.01) | 0.834 | −0.203 |
Cogstate OCL | 1 (0.98–1.02) | 0.95 (0.9–0.97) | 0.85 (0.82–0.93) | −0.07 (−0.08 – −0.03) | 0.114 | −1.767 | −0.15 (−0.17 – −0.08) | 0.114 | −1.751 |
Cogstate ONB | 1.21 (1.1–1.34) | 1.32 (1.22–1.34) | 1.16 (0.97–1.23) | −0.04 (−0.12–0.1) | 1 | −0.167 | −0.14 (−0.2 – −0.08) | 0.296 | −0.841 |
GDS | 3 (0.75–4.5) | 2 (1.75–2.25) | 4 (1.75–5.75) | 0 (−1.25–1) | 1 | 0 | 0 (−0.25–2.5) | 0.834 | 0 |
BAI | 5.5 (1.75–7) | 2.5 (1–9.5) | 7.5 (3.5–9.25) | −0.5 (−4 – 1.5) | 1 | −0.085 | 2 (0–2.5) | 0.338 | 0.974 |
Note: Bold formatting indicates significant results.
Abbreviations: p, adjusted p-value (Hochberg correction for multiple testing), d, effect size.