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. 2020 Aug 11;13:7973–7984. doi: 10.2147/OTT.S264108

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© 2020 Sun et al.

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USP8 inhibitor inhibits gastric cancer tumors growth in xenograft model. (A) USP8 inhibitor and si-USP8 cells were injected in MGC-803 group, which used as the control group. USP8 inhibitor and si-USP8 in NCI-N87 (B) and MKN-45 (C) cells. Bar graph represents the results of the average tumor weight (presented as the mean ± standard deviation). *P<0.05. (D) HER-3 and Ki-67 expression levels in tumor from mice bearing MGC-803, NCI-N87 and MKN-45 with USP8 inhibitor and si-USP8 treatment, and immunohistochemical staining (IHC) expression of Ki-67 and HER-3 in them. *P< 0.05.