Table 2:
Treatment and dose effect on hemodynamic variables
| Autonomic Measures | Dose effect | Treatment effect | |||
|---|---|---|---|---|---|
| carbidopa 300 mg/day | carbidopa 600-mg/day | p value | placebo | p value | |
| Ambulatory blood pressure monitoring | |||||
| 24-h average systolic mmHg | 113±10 | 112±8 | 0.4863 | 120±14 | 0.0679 |
| 24-h average diastolic mmHg | 68±9 | 67±8 | 0.3882 | 74±12 | 0.0286 |
| 24-h average heart rate bpm | 73±6 | 75±7 | 0.0541 | 79±7 | 0.0017 |
| Daytime average systolic mmHg | 113±8 | 114±11 | 0.6138 | 122±17 | 0.0659 |
| Daytime average diastolic mmHg | 68±8 | 68±8 | 0.5665 | 75±15 | 0.0196 |
| Nighttime average systolic mmHg | 111±10 | 111±12 | 0.2617 | 114±8 | 0.7096 |
| Nighttime average diastolic mmHg | 65±11 | 67±12 | 0.0571 | 67±7 | 0.3390 |
| 24-h SD systolic mmHg | 18±4 | 17±4 | 0.4263 | 23±6 | 0.0009 |
| 24-h SD diastolic mmHg | 17±4 | 17±5 | 0.9515 | 21±8 | 0.0195 |
| 24-h SD heart rate bpm | 10±4 | 10±3 | 0.1909 | 11±3 | 0.1805 |
| 24-h CV systolic mmHg | 15±3 | 16±4 | 0.7609 | 19±4 | 0.0007 |
| 24-h CV diastolic mmHg | 25±5 | 25±6 | 0.9515 | 28±7 | 0.0683 |
| 24-h CV heart rate bpm | 13±4 | 14±5 | 0.2734 | 13±4 | 0.6169 |
| Systolic peaks in 24h n | 3±1 | 5±4 | 0.0984 | 7±2 | 0.0019 |
| Diastolic peaks in 24h n | 4±3 | 5±4 | 0.7224 | 8±3 | 0.0469 |
| Systolic hypertensive range %time | 8±6 | 14±12 | 0.1272 | 19±6 | 0.0547 |
| Diastolic in hypertensive range %time | 14±12 | 12±10 | 0.3054 | 23±12 | 0.0198 |
| Highest systolic mmHg | 157±20 | 150±17 | 0.1433 | 174±27 | 0.0015 |
| Highest diastolic mmHg | 106±18 | 109±17 | 0.7490 | 123±25 | 0.0097 |
| Highest heart rate bpm | 97±20 | 99±13 | 0.1932 | 105±13 | 0.1409 |
| Lowest systolic mmHg | 82±8 | 79±6 | 0.0818 | 79±9 | 0.5314 |
| Lowest diastolic mmHg | 43±6 | 41±2 | 0.1953 | 42±7 | 0.5058 |
| Lowest heart rate bpm | 55±9 | 59±7 | 0.1382 | 60±10 | 0.0999 |
| OH dizziness score item 1 points | 1.7±2.3 | 1.7±2.6 | 0.9999 | 0.7±1.3 | 0.2904 |
| OH activities daily activities score | 16±12 | 12±10 | 0.5303 | 9±11 | 0.3743 |
| Office readings | |||||
| Supine systolic mmHg | 127±18 | 127±21 | 0.7960 | 126±26 | 0.9959 |
| Supine diastolic mmHg | 73±19 | 75±22 | 0.9515 | 73±20 | 0.9501 |
| Supine heart rate bpm | 72±13 | 78±13 | 0.2345 | 76±11 | 0.3252 |
| 3 min standing systolic mmHg | 91±28 | 96±24 | 0.6698 | 96±28 | 0.6968 |
| 3 min standing diastolic mmHg | 44±18 | 51±26 | 0.6589 | 50±23 | 0.4567 |
| 3 min standing heart rate bpm | 72±12 | 78±13 | 0.0933 | 78±11 | 0.2136 |
OH = orthostatic hypotension, SD = standard deviation. P values for treatment effect adjusted to account for multiple comparisons using the Bonferroni method. Systolic peaks defined as >135 mmHg during the day and >120 mmHg during the night. Diastolic peaks defined as > 85 mmHg during the day and >70 mmHg during the night. p value comparing 300 versus 600 mg/day doses determined using nonparametric Wilcoxon test. Data are mean ± standard deviation.