Figure 6: Impact of PABA analogs on the antibacterial activity of sulfamethoxazole (SMX).
(A) S. aureus Xen29 were incubated with SMX (0.048 μg/mL −100 μg/mL) either alone or in the presence of PABA (0.8 μg/mL and 4 μg/mL) demonstrating that PABA can rescue the inhibition of growth caused by SMX in a concentration-dependent manner. (B-D) F-PABA and 2-F-NB but not 2-F-NAP can rescue the inhibition of growth caused by SMX.