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. Author manuscript; available in PMC: 2021 Aug 5.
Published in final edited form as: J Am Chem Soc. 2020 Jul 24;142(31):13372–13383. doi: 10.1021/jacs.9b11950

Table 1.

Calculated dissociation constant values from experimental data and model fit.a

Dissociation Constant Value (M−1) Propagated Errorb
K1 9.4 × 10−7 0.74 × 10−7
K2 9.4 × 10−7 0.74 × 10−7
K3 4.9 × 10−5 0.28 × 10−5
K4 4.3 × 10−1 0.06 × 10−1
Ktetramer 1.1 × 10−12 (β = 2.7 × 1045M−9) 0.006 × 10−12
a

Dissociation constants were determined from the data presented in Figure 7.

b

First order approximation of the uncertainty in the fit parameters as propagated through the least squares fitting from the standard deviations of the replicate HDX measurements.