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. Author manuscript; available in PMC: 2021 Aug 14.
Published in final edited form as: ACS Infect Dis. 2020 Jul 14;6(8):2169–2180. doi: 10.1021/acsinfecdis.0c00258

Table 2.

Antimicrobial activity of 1, 2 and 15–24 against VanA VRE strains, MIC (μg/mL).

Compound VanA E. faecalis VanA E. faecium VanA E. faecalis VanA E. faecium
BM 4166 ATCC BAA-2317 ATCC BAA-2573 TX 2465
vancomycin (1) 250 250 125 250
CBP-vancomycin (2) 5 2.5 0.3 5
G3-CBP-vancomycin (15) 0.6 0.3 0.15 0.6
G2-CBP-vancomycin (16) 0.6 0.3 0.15 1.2
G4-CBP-vancomycin (17) 0.6 0.3 0.15 0.6
G6-CBP-vancomycin (18) 0.6 0.3 0.3 1.2
GBn-CBP-vancomycin (19) 0.6 0.3 0.15 0.6
Arg(OMe)-CBP-vancomycin (20) 0.6 0.3 0.15 0.6
Arg-CBP-vancomycin (21) 1.2 1.2 0.15 2.5
Arg(NH2)-CBP-vancomycin (22) 0.6 0.3 0.15 0.6
Cit(OMe)-CBP-vancomycin (23) 1.2 2.5 0.3 5
DiG-CBP-vancomycin (24) 0.6 0.6 0.15 0.3