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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Cancer Lett. 2020 Jun 5;489:50–55. doi: 10.1016/j.canlet.2020.05.033

Figure 1. Dual recombinase system for pancreatic cancer.

Figure 1.

Flp recombinase directs tumorigenesis in the target tissue by a tissue-specific Flp (in this case, Pdx1-FlpO), which activates Kras and knocks out Trp53. This leaves stromal components available to be regulated by the Cre/lox system where a gene of interest (GOI) can be manipulated as desired with a tissue-specific Cre.