Table 2.
Details of samples included in analyses.
| Study | Sample/Consortium | Phenotype(s) | Definition | Sample Size (cases / controls if binary) | Number of SNPs in summary statistics file |
|---|---|---|---|---|---|
| Eating Disorder Phenotype | |||||
| Watson et al. (in press) | PGC-ED | 1. Anorexia nervosa 2. Anorexia nervosa with binge-eating 3. Anorexia nervosa without binge-eating |
DSM-III-R, DSM-IV, ICD-8, ICD-9, ICD-10, or self-reported anorexia nervosa | 16,992 / 55,525 2,381 / 10,249 2,262 / 10,254 |
8,219,102 8,982,440 8,671,192 |
| Wade et al. (2013) | Australian Twin Registry | Bulimia nervosa factor | Eating Disorder Examination | 151 / 2,291 | 6,150,213 |
| Substance Use-Related Phenotype | |||||
| Kranzler et al. (2019) | MVP | Alcohol use disorder | ICD-9 or ICD-10 | 34,658 / 167,346 | 6,895,251 |
| Walters et al. (2018) | PGC-SUD | Alcohol dependence | DSM-IV | 8,485 / 20,272 | 9,271,145 |
| Liu et al. (2019) | GSCAN | 1. Drinks per week* 2. Smoking initiation 3. Current smokinga 4. Cigarettes per day* |
Average number of drinks each week Ever vs. never regular smoker Current vs. former smokers Average number of cigarettes smoked per day |
537,349 311,629 / 321,173 92,573 / 220,248 263,954 |
11,916,707 11,733,344 12,197,133 12,003,613 |
| Hancock et al. (2017) | 14 consortia | Nicotine dependence** | Mild (FTND score 0–3), Moderate (FTND score 4–6), or Severe (FTND score 7–10) | 14,184 (Mild) 9,206 (Moderate) 5,287 (Severe) |
10,622,668 |
| Pasman et al. (2018) | ICC UK Biobank |
Cannabis initiation | Lifetime cannabis use | 43,380 / 118,702 | 11,733,371 |
| Demontis et al. (2019) | iPSYCH | Cannabis use disorder | ICD-10 | 2,387 / 48,985 | 8,969,939 |
Note: SNPs=single nucleotide polymorphisms; PGC-ED=Eating Disorders Working Group of the Psychiatric Genomics Consortium; DSM=Diagnostic and Statistical Manual; ICD=International Classification of Diseases; PGC-SUD=Substance Use Disorders Working Group of the Psychiatric Genomics Consortium; MVP=Million Veteran Program; GSCAN=GWAS & Sequencing Consortium of Alcohol and Nicotine use; FTND=Fagerstrӧm Test of Nicotine Dependence; ICC=International Cannabis Consortium; iPSYCH=Lundbeck Foundation Initiative for Integrative Psychiatric Research.
Treated as a continuous phenotype.
Treated as an ordinal phenotype.
In Lui et al. (2019), the phenotype is labeled as “smoking cessation”. It was renamed as “current smoking” to reflect the coding scheme and for ease in comparing across all smoking phenotypes.