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. Author manuscript; available in PMC: 2021 Aug 21.
Published in final edited form as: J Mater Chem B. 2020 Jun 17;8(31):6588–6609. doi: 10.1039/d0tb00681e

Figure 4. Multifunctional CVD polymer thin films for biological sensing.

Figure 4.

(A) Fabrication (i) and application (ii) of the substrates used to amplify fluorescent signals. Gold-coated glass was functionalized with poly(p-xylylene) thin films via CVD polymerization, which allowed the subsequently immobilization of fluorophores via physical adsorption or covalent bonds. The functionalized substrate enabled real‐time monitoring of FITC‐BSA adsorption. (B) Fabrication (i) and application (ii) of the substrates used to monitor antibody binding kinetics. Functionalized poly(p-xylylene) thin films allowed the immobilization of Epidermal Growth Factor (EGF) and subsequently a primary antibody (anti-EGF), enabling the monitor of binding kinetics of a secondary antibody conjugated with the Alexa 647 (a fluorophore) to the primary antibody.121 Copyright 2016, reproduced with permission from John Wiley and Sons.