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. Author manuscript; available in PMC: 2021 Aug 10.
Published in final edited form as: J Control Release. 2020 Jun 3;324:610–619. doi: 10.1016/j.jconrel.2020.05.046

Figure 1. The DR5 pathway is upregulated in pancreatic cancer and correlates with poorer prognosis.

Figure 1

(A) Simplified schematic of the DR5 pathway (B) Disease free survival plots comparing high and low expressers of genes in the DR5 pathway including TNFRSF10B (DR5), CFLAR (FLIP), CASP8 (caspase 8) and FADD (FADD) using RNAseq data from GEPIA.com showing poorer prognosis in high expressors. (C) Correlation plots comparing expression levels of apoptotic pathway genes using RNAseq data from GEPIA.com showing a positive correlation in expression between all genes investigated.